Ma ʻApelila 15, 2022, ua hoʻopau ʻia ka hana hoʻokele o Lecardipine hydrochloride apo nui i ka manawa hoʻokahi, a ʻo ka mana hana o kēia manawa he 5Mt / mahina.
inoa Pelekania:Lercanidipine hydrochloride
inoa kemika:1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2- [(3,3-di phenylpropyl)methylamino]-l,l-dimethylethyl methyl ester hydrochloride.
Helu CAS: 132866-11-6
Noi:No ka mālama ʻana i ka lāʻau lapaʻau Lecardipine hydrochloride, ʻaʻole ia e loaʻa ka hopena maikaʻi ʻole i ke koko glucose a me nā pae lipid, a he hopena antihypertensive ikaika.
Manaʻo mākeke:
Aia ma mua o 200 miliona mau maʻi hypertensive ma Kina, a aia he 10 miliona mau maʻi hypertensive hou i kēlā me kēia makahiki, ʻo ka hapa nui o ia mau mea ʻaʻole i lalo o ka mana, ka hopena i kahi kiʻekiʻe o nā pilikia hypertension e like me ka hahau ʻana, a me ka make makahiki ma Kina Ma waena o 3 miliona mau maʻi me ka maʻi cardiovascular, 50% pili i ke kiʻekiʻe kiʻekiʻe, a ʻo ke kumukūʻai makahiki o ka mālama ʻana i ka maʻi cardiovascular ma kahi o 309.8 biliona yuan.ʻO ke kumu o ka maikaʻi ʻole o ka mālama ʻana, ʻaʻole wale ka ʻike o ka poʻe maʻi i ka hypertension a me nā pilikia e pono ai ke hoʻomaikaʻi ʻia, akā, ʻo ka nui o nā maʻi e pono ai e lawe i ka lāʻau lapaʻau i ke ola holoʻokoʻa ʻaʻole hiki ke lawe i ka lāʻau i kēlā me kēia lā. Hiki ke hoʻonui ʻia ka mākeke lāʻau antihypertensive.Ke hoʻohālikelike ʻia me nā lāʻau like ʻole, loaʻa i ka locarbodipine hydrochloride kahi koho vascular ikaika.ʻO kāna waiwai lipophilic kū hoʻokahi e lohi a mau loa ka hopena antihypertensive ʻO ka hopena atherogenic, kūpono loa i nā maʻi hypertension me ka atherosclerosis, loaʻa ka waiwai noiʻi lapaʻau kiʻekiʻe a me ka manaʻolana ākea ākea.
Nā hana lāʻau lapaʻau:
ʻO Lecardipine kahi hanauna hou o ka dihydropyridine calcium channel group hysteresis agent, me ka ikaika vascular selectivity, ka hopena mālie, ka hopena antihypertensive ikaika, ka manawa hana lōʻihi, ka hopena inotropic maikaʻi ʻole a pēlā aku.Ua ʻike ʻia nā haʻawina in vitro he hopena hoʻomaha pololei ka locarbodipine i ka ʻiʻo maʻemaʻe vascular, a no laila he hopena antihypertensive ikaika i loko o vivo, akā liʻiliʻi ka hopena o ka puʻuwai a me ka puka ʻana o ka naʻau.Ma muli o kona nui hydrophobic gene a me ka ikaika o ka lipid solubility, ua puʻunaue koke ʻia ka locarbodipine i nā ʻiʻo a me nā ʻōpū ma hope o ke komo ʻana i ke kino, pili loa i ka membrane cell muscle vascular smooth, a hoʻokuʻu mālie.No laila, ʻoiai ʻo ka serum o kēia lāʻau lapaʻau he manawa hoʻopau pōkole o ka hapa hapa, ua lōʻihi kona hopena.
Ka manawa hoʻouna: Apr-15-2022